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Site - clsASite clsA Site clsA
- Name: clsA
- Type: Gene
- Synonyms
|
| b1249 | MG1655 locus tag |
| nov | Ivanisevic et al. |
- Mnemonic: cardiolipin synthase
- Left End Point: 28.13
- Right End Point: 28.17
- Direction: <
- Priority: 1
- External Database Links:
- Comment:
- Selectable phenotype: Dihydroxybutyl 1-phosphonate resistance. Mutants have incr. sens. to novobiocin and reduced levels of cardiolipin.
- References:
- Hwang, Y.-W., R. Engel, B.E. Troop 1984. Correlation of 3,4-dihydroxybutyl 1-phosphonate resistance with a defect in cardiolipin synthesis in Escherichia coli. J.Bacteriol. 157:846-856
- Ohta, A., T. Obara, Y. Asami, I. Shibuya 1985. Molecular cloning of the cls gene responsible for cardiolipin synthesis in Escherichia coli and phenotypic consequences of its amplification. J.Bacteriol. 163:506-514
- Nishijima, M., Y. Asami, N. Uetake, S. Yamagoe, A. Ohta, I. Shibuya 1988. Disruption of the Escherichia coli cls gene responsible for cariolipin synthesis. J.Bacteriol. 170:775-780
- Hiraoka, S., K. Nukui, N. Uetake, A. Ohta, I. Shibuya 1991. Amplification and substantial purification of cardiolipin synthase of Escherichia coli. J.Biochem.(Tokyo) 110:443-449
- Heber, S., B.E. Tropp 1991. Genetic regulation of cardiolipin synthase in Escherichia coli. Biochim.Biophys.Acta 1129:1-12
- Hiraoka, S., H. Matsuzaki, I. Shibuya 1993. Active increase in cardiolipin synthesis in the stationary growth phase and its physiological significance in Escherichia coli. FEBS Lett. 336:221-224
- Tropp, B.E., L. Ragolia, W. Xia, W. Dowhan, R. Milkman, K.E. Rudd, R. Ivanisevic, D.J. Savic 1995. Identity of the Escherichia coli cls and nov genes. J.Bacteriol. 177:5155-5157
- Ivanisevic, R., M. Milic, D. Ajdic, J. Rakonjac, D.J. Savic 1995. Nucleotide sequence, mutational analysis, transcriptional start site, and product analysis of nov, the gene which affects Escherichia coli K-12 resistance to the gyrase inhibitor novobio
- Tropp, B.E. 1997. Cardiolipin synthase from Escherichia coli. Biochim.Biophys.Acta 1348:192-200
