Site wzxE
- Name: wzxE
- Type: Gene
- Synonyms
b3792 MG1655 locus tag wzx - Mnemonic: Temporary systematic nomenclature
- Left End Point: 85.66
- Right End Point: 85.69
- Products:
mambrane protein, translocase, involved in movement of Lipid III across bilayer of cytopl.memb. translocase/flippase translocating Und-P-P-linked units of O antigens - Direction: >
- Properties:
Property Comment encodes membrane protein translocates O-antigen subunits - Priority: 0
- 1 Alleles of This Gene
wzxE743(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG11486 EcoliWiki wzxE - Comment:
- Null mutants accumulate lipid III and die, unless also rfe- (wecA-), making them unable to synthesize lipid III. Putative transporter Wzx flips O-antigen from inner to outer surface of IM.
- References:
- Rick, P.D., K. Barr, K. Sankaran, J. Kajimura, J.S. Rush, C.J. Waechter 2003. Evidence that the wzxE gene of Escherichia coli K-12 encodes a protein involved in the transbilayer movement of a trisaccharide-lipid intermediate in the assembly of enteroba
- Raetz, C.R., C.M. Reynolds, M.S. Trent, R.E. Bishop 2007. Lipid A modification systems in gram-negative bacteria. Annu.Rev.Biochem. 76:295-329