About the CGSC
Searching the CGSC Database
How to Request Strains or Information
Site - dinBSite dinB Site dinB
- Name: dinB
- Type: Gene
- Synonyms
|
| b0231 | MG1655 locus tag |
| dinP | |
- Mnemonic: damage-inducible
- Left End Point: 5.41
- Right End Point: 5.43
- Direction: >
- Properties:
| Property | Comment |
|---|
| SOS-related | SOS-induced mutagenesis |
- Priority: 0
- External Database Links:
- Comment:
- similar sequence to UmuC protein. Appears to induce mutagenesis independently of umuDC and in absence of exogenous damage to DNA. Increased mutagenesis of lambda in UV-irradiated cells requires dinP
- References:
- Brotcorne-Lannoye, A., G. Maenhaut-Michel 1986. Role of RecA protein in untargeted UV mutagenesis of bacteriophage lambda: evidence for the requirement for the dinB gene. Proc.Natl.Acad.Sci.USA 83:3904-3908
- Kim, S.R., G. Maenhaut-Michel, M. Yamada, Y. Yamamoto, K. Matsui, T. Sofuni, T. Nohmi, H. Ohmori 1997. Multiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of dinB/dinP results in strongly enhancing mutagenesis in the ab
- Wagner, J., P. Gruz, S.R. Kim, M. Yamada, K. Matsui, R.P. Fuchs, T. Nohmi 1999. The dinB gene encodes a novel E.coli DNA polymerase, DNA pol IV, involved in mutagenesis. Mol Cell 4:281-286
- Wagner, J., T. Nohmi 2000. Escherichia coli DNA polymerase IV mutator activity: genetic requirements and mutational specificity. J.Bacteriol. 182:4587-4595
