Site rimK
- Name: rimK
- Type: Gene
- Synonyms
b0852 MG1655 locus tag nek neomycin/kan resist., multiple muts including rimK - Mnemonic: ribosomal modification
- Left End Point: 19.21
- Right End Point: 19.23
- Direction: >
- Priority: 0
- 2 Alleles of This Gene
rimK728 rimK753(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG10852 EcoliWiki rimK - Comment:
- RimK modifies ribosomal protein S6 by adding up to 4 glutamic acid residues to C-terminus. Selectable phenotype: neomycin, kan resistance (now chloramphenicol sensitive); amikacin, gentamicinR
- References:
- Apirion, D., D. Schlessinger 1968. Coresistance to neomycin and kanamycin by mutations in an Escherichia coli locus that affects ribosomes. J.Bacteriol. 96:768-776
- Hull, R., J.D. Klinger, E.E.M. Moody 1976. Isolation and characterization of mutants of Escherichia coli K12 resistant to the new aminoglycoside antibiotic, amikacin. J.Gen.Microbiol. 94:389-394
- Kang, W.K., T. Icho, S. Isono, M. Kitakawa, K. Isono 1989. Characterization of the gene rimK responsible for the addition of glutamic acid residues to the C-terminus of ribosomal protein S6 in Escherichia coli K12. Mol.Gen.Genet. 217:281-288