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CGSC, The Coli Genetic Stock Center

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Site nhaB

• Name: nhaB
• Type: Gene
  Synonyms

  b1186	MG1655 locus tag

  
  
• Mnemonic: Na+ H+ antiporter; old ant=antiporter
• Left End Point: 26.57
• Right End Point: 26.60
  Products:

  Na+/H+ antiporter

  
  
• Direction: <
• Priority: 0
  2 Alleles of This Gene

  nhaB3(del)::Cm

  nhaB775(del)::kan

  
  
• External Database Links:

  Host Site	Page Links
  EcoGene.org	EG11392
  EcoliWiki	nhaB

  
  
• Comment:
  • regulator of intracellular pH. NhaB functions at pH below 8.
• References:
  • Padan, E., N. Maisler, D. Taglicht, R. Karpel, S. Schuldiner 1989. Deletion of ant in Escherichia coli reveals its function in adaptation to high salinity and an alternative Na+/H+ antiporter systems(s). J.Biol.Chem. 264:20297-20302
  
  
  • Thelen, P., T. Tsuchiya, E.B. Goldberg 1991. Characterization and mapping of a major Na+/H+ antiporter gene of Escherichia coli. J.Bacteriol. 173:6553-6557
  
  
  • Ohyama, T., R. Imaizumi, K. Igarashi, H. Kobayashi 1992. Escherichia coli is able to grow with negligible sodium ion extrusion activity at alkaline pH. J.Bacteriol. 174:7743-7749
  
  
  • Kayahara, T., P. Thelen, W. Ogawa, K. Inaba, M. Tsuda, E.B. Goldberg, T. Tsuchiya 1992. Properties of recombinant cells capable of growing on serine without NhaB Na+/H+ antiporter in Escherichia coli. J.Bacteriol. 174:7482-7485
  
  
  • Pinner, E., E. Padan, S. Schuldiner 1992. Cloning, sequencing, and expression of the nhaB gene, encoding a Na+/H+ antiporter in Escherichia coli. J.Biol.Chem. 267:11064-11068
  
  
  • Padan, E., S. Schuldiner 1993. Na+/H+ antiporters, molecular devices that couple the Na+ and H+ circulation in cells. J.Bioenerg.Biomembr. 25:647-669
  
  
  • Pinner, E., Y. Kotler, E. Padan, S. Schuldiner 1993. Physiological role of nhaB, a specific Na+/H+ antiporter in Escherichia coli. J.Biol.Chem. 268:1729-1734
  
  
  • Verkhovskaya, M.L., M.I. Verkhovsky, M. Wikstrom 1996. The respiration-driven active sodium transport system in E.coli does not function with lithium. FEBS Lett. 388:217-218
  
  
  • Sakuma, T., N. Yamada, H. Saito, T. Kakegawa, H. Kobayashi 1998. pH dependence of the function of sodium ion extrusion systems in Escherichia coli. Biochim.Biophys.Acta 1363:231-237