About the CGSC
Searching the CGSC Database
How to Request Strains or Information
Site - vsrSite vsr Site vsr
- Name: vsr
- Type: Gene
- Synonyms
|
| b1960 | MG1655 locus tag |
- Mnemonic: very short (patch) repair
- Left End Point: 43.72
- Right End Point: 43.73
- Direction: <
- Properties:
| Property | Comment |
|---|
| repair system gene | NULL |
- Priority: 0
- External Database Links:
- Comment:
- shares common promoter with dcm; 5' of coding region overlaps 3' of dcm, but not in frame. minimizes effects of C methylation.
- References:
- Bhagwat, A.S., A. Sohail, M. Lieb 1988. A new gene involved in mismatch correction in mismatch correction in Escherichia coli. Gene 74:155-156
- Sohail, A., M. Lieb, M. Dar, A.S. Bhagwat 1990. A gene required for very short patch repair in Escherichia coli is adjacent to the DNA cytosine methylase gene. J.Bacteriol. 172:4214-4221
- Lieb, M. 1991. Spontaneous mutation at a 5-methylcytosine hotspot is prevented by very short patch VSP mismatch repair. Genetics 128:23-28
- Hennecke, F., H. Kolmar, K. Brundl, H.J. Fritz 1991. The vsr gene product of E.coli K-12 is a strand- and sequence-specific DNA mismatch endonuclease. Nature 353:776-778
- Lieb, M., S. Rehmat 1995. Very short patch repair of T:G mismatches in vivo: importance of context and accessory proteins. J.Bacteriol. 177:660-666
- Macintyre, G., K.M. Doiron, C.G. Cupples 1997. The Vsr endonuclease of Escherichia coli: an efficient DNA repair enzyme and a potent mutagen. J.Bacteriol. 179:6048-6052
- Foster, P.L., W.A. Rosche 1998. Levels of the Vsr endonuclease do not regulate stationary-phase reversion of a lac- frameshift allele in Escherichia coli. J.Bacteriol. 180:1944-1946
- Gonzalez-Nicieza, R., D.P. Turner, B.A. Connolly 2001. DNA binding and cleavage selectivity of the Escherichia coli DNA G:T-mismatch endonuclease (vsr protein). J.Mol.Biol. 310:501-508
