Site fhlA
- Name: fhlA
- Type: Gene
- Synonyms
b2731 MG1655 locus tag - Mnemonic: formate hydrogen-lyase
- Left End Point: 61.48
- Right End Point: 61.53
- Products:
transcription factor, formate hydrogenlyase system - Direction: >
- Properties:
Property Comment formate regulon member global regulator; transcriptional activator encodes NA-binding protein transcriptional activator, Sigma54-dependent - Priority: 1
- 1 Alleles of This Gene
fhlA735(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG10301 EcoliWiki fhlA - Comment:
- Formate hydrogen-lyase system activator. sigma 54-dependent. responds to formate concentration at low pH.
- References:
- Sankar, P., J.H. Lee, K.T. Shanmugam 1985. Cloning of hydrogenase genes and the fine structure of an operon essential for H2 metabolism in Escherichia coli. J.Bacteriol. 162:353-360
- Sankar, P., J.H. Lee, K.T. Shanmugam 1988. Gene-product relationships of fhlA and fdv genes of Escherichia coli. J.Bacteriol. 170:5440-5445
- Schlensog, V., A. Bock 1990. Identification and sequence analysis of the gene encoding the transcriptional activator of the formate hydrogenlyase system of Escherichia coli. Mol.Microbiol. 4:1319-1327
- Rossmann, R., G. Sawers, A. Bock 1991. Mechanism of regulation of the formate-hydrogenlyase pathway by oxygen, nitrate, and pH: definition of the formate regulon. Mol.Microbiol. 5:2807-2814
- Iuchi, S., E.C.C. Lin 1993. Adaptation of Escherichia coli to redox environments by gene expression. Mol.Microbiol. 9:9-15
- Schlensog, V., S. Lutz, A. Bock 1994. Purification and DNA-binding properties of FHLA, the transcriptional activator of the formate hydrogenlyase system from Escherichia coli. J.Biol.Chem. 269:19590-19596
- Hopper, S., M. Babst, V. Schlensog, H.M. Fischer, H. Hennecke, A. Bock 1994. Regulated expression in vitro of genes coding for formate hydrogenlyase components of Escherichia coli. J.Biol.Chem. 269:19597-19604
- Hopper, S., A. Bock 1995. Effector-mediated stimulation of ATPase activity by the Sigma^54 dependent transcriptional activator FHLA from Escherichia coli. J.Bacteriol. 177:2798-2803