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Site - nikASite nikA Site nikA
- Name: nikA
- Type: Gene
- Synonyms
|
| b3476 | MG1655 locus tag |
| hydC | pre-1991 |
- Mnemonic: nickel
- Left End Point: 77.84
- Right End Point: 77.88
- Direction: >
- Priority: 1
- External Database Links:
- Comment:
- affects formate hydrogenlyase activity; hydrogenase and hydrogenase-related functions impaired in mutants,restored by addition of nickel. Probably nickel transport system, but see Stoker et al.
- References:
- Wu, L.F., M.A. Mandrand-Berthelot 1986. Genetic and physiological characterization of new Escherichia coli mutants impaired in hydrogenase activity. Biochimie 68:167-179
- Stoker, K., L.F. Oltmann, A.H. Stouthamer 1989. Randomly induced Escherichia coli K-12 Tn5 insertion mutants defective in hydrogenase activity. J.Bacteriol. 171:831-836
- Wu, L.F., M.A. Mandrand-Berthelot, R. Waugh, C.J. Edmonds, S.E. Holt, D.H. Boxer 1989. Nickel deficiency gives rise to the defective hydrogenase phenotype of hydC and fnr mutants in Escherichia coli. Mol.Microbiol. 3:1709-1718
- Wu, L.F., C. Navarro, M.A. Mandrand-Berthelot 1991. The hydC region contains a multi-cistronic operon (nik) involved in nickel transport in Escherichia coli. Gene 107:37-42
- Navarro, C., L.F. Wu, M.A. Mandrand-Berthelot 1993. The nik operon of Escherichia coli encodes a periplasmic binding-protein-dependent transport system for nickel. Mol.Microbiol. 9:1181-1191
- Furuya, N., T. Komano 1995. Specific binding of the NikA protein to one arm of 17-base-pair inverted repeat sequences within the oriT region of plasmid R64. J.Bacteriol. 177:46-51
